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Snakes and lizards (Squamata) represent a third of terrestrial vertebrates and exhibit spectacular innovations in locomotion, feeding, and sensory processing. However, the evolutionary drivers of this radiation remain poorly known. We infer potential causes and ultimate consequences of squamate macroevolution by combining individual-based natural history observations (>60,000 animals) with a comprehensive time-calibrated phylogeny that we anchored with genomic data (5400 loci) from 1018 species. Due to shifts in the dynamics of speciation and phenotypic evolution, snakes have transformed the trophic structure of animal communities through the recurrent origin and diversification of specialized predatory strategies. Squamate biodiversity reflects a legacy of singular events that occurred during the early history of snakes and reveals the impact of historical contingency on vertebrate biodiversity. 

Abstract Crooked Ridge and White Mesa in northeastern Arizona (southwestern United States) preserve, as inverted topography, a 57-km-long abandoned alluvial system near the present drainage divide between the Colorado, San Juan, and Little Colorado Rivers. The pathway of this paleoriver, flowing southwest toward eastern Grand Canyon, has led to provocative alternative models for its potential importance in carving Grand Canyon. The ∼50-m-thick White Mesa alluvium is the only datable record of this paleoriver system. We present new 40Ar/39Ar sanidine dating that confirms a ca. 2 Ma maximum depositional age for White Mesa alluvium, supported by a large mode (n = 42) of dates from 2.06 to 1.76 Ma. Older grain modes show abundant 37–23 Ma grains mostly derived ultimately from the San Juan Mountains, as is also documented by rare volcanic and basement pebbles in the White Mesa alluvium. A tuff with an age of 1.07 ± 0.05 Ma is inset below, and hence provides a younger age bracket for the White Mesa alluvium. Newly dated remnant deposits on Black Mesa contain similar 37–23 Ma grains and exotic pebbles, plus a large mode (n = 71) of 9.052 ± 0.003 Ma sanidine. These deposits could be part of the White Mesa alluvium without any Pleistocene grains, but new detrital sanidine data from the upper Bidahochi Formation near Ganado, Arizona, have similar maximum depositional ages of 11.0–6.1 Ma and show similar 40–20 Ma San Juan Mountains–derived sanidine. Thus, we tentatively interpret the <9 Ma Black Mesa deposit to be a remnant of an 11–6 Ma Bidahochi alluvial system derived from the now-eroded southwestern fringe of the San Juan Mountains. This alluvial fringe is the probable source for reworking of 40–20 Ma detrital sanidine and exotic clasts into Oligocene Chuska Sandstone, Miocene Bidahochi Formation, and ultimately into the <2 Ma White Mesa alluvium. The <2 Ma age of the White Mesa alluvium does not support models that the Crooked Ridge paleoriver originated as a late Oligocene to Miocene San Juan River that ultimately carved across the Kaibab uplift. Instead, we interpret the Crooked Ridge paleoriver as a 1.9–1.1 Ma tributary to the Little Colorado River, analogous to modern-day Moenkopi Wash. We reject the “young sediment in old paleovalley” hypothesis based on mapping, stratigraphic, and geomorphic constraints. Deep exhumation and beheading by tributaries of the San Juan and Colorado Rivers caused the Crooked Ridge paleotributary to be abandoned between 1.9 and 1.1 Ma. Thermochronologic data also provide no evidence for, and pose substantial difficulties with, the hypothesis for an earlier (Oligocene–Miocene) Colorado–San Juan paleoriver system that flowed along the Crooked Ridge pathway and carved across the Kaibab uplift. 

Abstract AimSquamate fitness is affected by body temperature, which in turn is influenced by environmental temperatures and, in many species, by exposure to solar radiation. The biophysical drivers of body temperature have been widely studied, but we lack an integrative synthesis of actual body temperatures experienced in the field, and their relationships to environmental temperatures, across phylogeny, behaviour and climate. LocationGlobal (25 countries on six continents). TaxaSquamates (210 species, representing 25 families). MethodsWe measured the body temperatures of 20,231 individuals of squamates in the field while they were active. We examined how body temperatures vary with substrate and air temperatures across taxa, climates and behaviours (basking and diel activity). ResultsHeliothermic lizards had the highest body temperatures. Their body temperatures were the most weakly correlated with substrate and air temperatures. Body temperatures of non‐heliothermic diurnal lizards were similar to heliotherms in relation to air temperature, but similar to nocturnal species in relation to substrate temperatures. The correlation of body temperature with air and substrate temperatures was stronger in diurnal snakes and non‐heliothermic lizards than in heliotherms. Body‐substrate and body‐air temperature correlations varied with mean annual temperatures in all diurnal squamates, especially in heliotherms. Thermal relations vary with behaviour (heliothermy, nocturnality) in cold climates but converge towards the same relation in warm climates. Non‐heliotherms and nocturnal species body temperatures are better explained by substrate temperature than by air temperature. Body temperature distributions become left‐skewed in warmer‐bodied species, especially in colder climates. Main ConclusionsSquamate body temperatures, their frequency distributions and their relation to environmental temperature, are globally influenced by behavioural and climatic factors. For all temperatures and climates, heliothermic species' body temperatures are consistently higher and more stable than in other species, but in regions with warmer climate these differences become less pronounced. A comparable variation was found in non‐heliotherms, but in not nocturnal species whose body temperatures were similar to air and substrate irrespective of the macroclimatic context. 

Abstract Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood^1–3. Here, the Molecular Transducers of Physical Activity Consortium⁴profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and femaleRattus norvegicusover eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (https://motrpac-data.org/).